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Drug intelligence / Profile preview
VE-PTP blocking antibody
- Development stage
- Preclinical
- Lead developer
- Johnson & Johnson
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
01
Overview
VE-PTP blocking antibody refers to monoclonal antibodies designed to target and inhibit vascular endothelial protein tyrosine phosphatase (VE-PTP, also known as PTPRB), an endothelial-specific transmembrane phosphatase that negatively regulates the Tie-2 receptor. Preclinical research, including studies by Janssen Research and Development, has investigated these antibodies for their ability to induce Tie-2 phosphorylation and protect against VEGF-A-induced vascular permeability. While genetic deletion of VE-PTP has shown protective effects against renal injury, preclinical evaluation of an extracellular domain (ECD)-targeting VE-PTP blocking antibody in mouse models of severe diabetic kidney disease (DKD) did not significantly improve urinary albumin-to-creatinine ratios or ameliorate hypertension- and diabetes-induced albuminuria.
- Other names
- anti-PTPRB antibodyanti-VE-PTP antibodyextracellular domain targeting VE-PTP blocking antibody
02
Targets
PTPRB (Vascular endothelial-protein tyrosine phosphatase)
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