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vebicorvir + entecavir
- Development stage
- Unknown
- Lead developer
- Assembly Biosciences
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Vebicorvir + entecavir is a **combination therapy** for chronic hepatitis B virus (HBV) infection, consisting of vebicorvir, an investigational HBV core inhibitor, and entecavir, a nucleoside reverse transcriptase inhibitor. **Vebicorvir** disrupts multiple aspects of HBV replication by targeting the viral core protein, while **entecavir** inhibits HBV DNA polymerase (reverse transcriptase), preventing viral DNA synthesis and replication. Administered together, they provide enhanced antiviral activity compared to entecavir alone and are being studied primarily in treatment-naïve chronic HBV patients. The combination is aimed at deeper HBV suppression and improved rates of HBV DNA and RNA decline, with a favorable safety and tolerability profile in early clinical trials[1][6].
- Brand names
- Baraclude (entecavir)
- Other names
- vebicorvirentecavir
02
Targets
HBc (Hepatitis B virus core protein)HBV Pol (Hepatitis B virus polymerase)
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