vecuronium

Vecuronium is a non-depolarizing neuromuscular blocking agent (NMBA) belonging to the aminosteroid class. It functions as a competitive antagonist at the nicotinic acetylcholine receptors (nAChR) located at the motor endplate of the neuromuscular junction. By binding to these receptors, vecuronium prevents the neurotransmitter acetylcholine from initiating muscle depolarization, resulting in reversible skeletal muscle paralysis. It is primarily indicated as an adjunct to general anesthesia to facilitate endotracheal intubation and to provide muscle relaxation during surgical procedures or mechanical ventilation. Developed by Organon, vecuronium is characterized by an intermediate duration of action and a lack of significant cardiovascular side effects or histamine release, making it a preferred choice in various clinical settings.

Brand names

Norcuron万可松

Other names

vecuronium bromide维库溴铵