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VEGF neutralizing antibody
- Development stage
- Unknown
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Intravitreal
01
Overview
A VEGF neutralizing antibody is a type of monoclonal antibody designed to bind to and neutralize vascular endothelial growth factor (VEGF), a key signaling protein that promotes angiogenesis (the formation of new blood vessels). By blocking the interaction of VEGF with its receptors (VEGFR1 and VEGFR2) on endothelial cells, these antibodies inhibit pathological neovascularization, vascular permeability, and tumor angiogenesis. This class of therapeutics is widely utilized in oncology to starve tumors of their blood supply and in ophthalmology to treat neovascular eye diseases such as wet age-related macular degeneration (AMD) and diabetic macular edema.
- Other names
- anti-VEGF antibodyanti-VEGF neutralizing antibodyanti-VEGFA neutralizing antibodyVEGF neutralizing antibodyVEGF-neutralizing antibody
02
Targets
VEGFA (Vascular endothelial growth factor A)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR2 (Vascular endothelial growth factor receptor 2)
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