VEGFR 2 Kinase inhibitor I

VEGFR 2 Kinase inhibitor I is an experimental small molecule that selectively inhibits the tyrosine kinase activity of vascular endothelial growth factor receptor 2 (VEGFR-2). By binding to the ATP-binding site of VEGFR-2 and preventing its phosphorylation, it blocks downstream signaling pathways involved in angiogenesis. This inhibition leads to reduced migration and proliferation of endothelial cells and suppression of new blood vessel formation (angiogenesis), which is critical for tumor growth and metastasis. The compound has been studied primarily as an anti-cancer agent due to its ability to disrupt tumor vascularization[1][4][2].

Other names

3-(2,4-dimethyl-3-ethoxycarbonylpyrrol-5-methylidenyl)-2-indolinoneEthyl 2,4-dimethyl-5-(((3z)-2-oxo-2,3-dihydro-1h-indol-3-ylidene)methyl)-1h-pyrrole-3-carboxylateVegf receptor 2 kinase inhibitor iVegfr-2 inhiVegfr2 inhiVegfr 2 inhi