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Velimixin
- Development stage
- Unknown
- Lead developer
- Venus Remedies
- Modality
- Peptides, Small Molecules
- Administration
- Intravenous
01
Overview
Velimixin is a supramolecular cationic (SMC) formulation of polymyxin B developed by Venus Remedies using its proprietary RENAL GUARD™ technology. This formulation is designed to mitigate the nephrotoxicity typically associated with polymyxin B while maintaining its potent bactericidal activity against multidrug-resistant (MDR) Gram-negative bacteria. Velimixin works by targeting and disrupting the outer cell membrane of Gram-negative pathogens through binding to lipopolysaccharides (LPS). It is approved and marketed in India for the treatment of bloodstream infections (bacteremia) and invasive infections caused by susceptible strains of *Acinetobacter* spp., *Pseudomonas aeruginosa*, *Escherichia coli*, and *Klebsiella* spp.
- Brand names
- Velimixin
- Other names
- Polymyxin B (SMC formulation)Polymyxin B (RENAL GUARD formulation)
02
Targets
LPS (Lipopolysaccharide)
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