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VEN100

Development stage
Unknown
Lead developer
Ventria Bioscience
Administration
Oral
01

Overview

VEN100 is an orally administered, recombinant human lactoferrin‑based product developed by Ventria Bioscience to prevent or reduce antibiotic‑associated diarrhea (AAD) in high‑risk patients. In a randomized, placebo‑controlled phase 2 trial, VEN100 reduced the incidence of antibiotic‑associated diarrhea by roughly 50% in hospitalized patients at elevated risk for AAD, supporting a role in maintaining gut mucosal integrity and modulating the intestinal microbiome and immune response during systemic antibiotic therapy. The product is derived from recombinant technology in a plant‑based system and is being positioned as a supportive care therapy around antibiotic use rather than as an antibiotic itself.[2][14]

Brand names
Lactiva
Other names
recombinant human lactoferrinrhLF
02

Targets

CD14 (Monocyte differentiation antigen CD14)HSPG (Basement membrane-specific heparan sulfate proteoglycan core protein (perlecan))

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