Venezuelan equine encephalitis vaccine TC-83

TC-83 is a live-attenuated vaccine developed by the U.S. Army to provide protection against the Venezuelan equine encephalitis virus (VEEV). It was derived from the wild-type Trinidad Donkey (TrD) strain of VEEV through 83 serial passages in fetal guinea pig heart cells. The vaccine is primarily administered to laboratory workers, military personnel, and other individuals at high occupational risk of exposure to VEEV. While it is effective at inducing neutralizing antibodies in approximately 80% of recipients, it is associated with a high rate of reactogenicity, often causing flu-like symptoms. In cases where TC-83 fails to elicit an adequate immune response, it is sometimes followed by a booster of the formalin-inactivated C-84 vaccine. It remains an Investigational New Drug (IND) in the United States.

Other names

VEE vaccine TC-83Live attenuated VEE vaccineVenezuelan equine encephalomyelitis vaccine