Drug intelligence / Profile preview

venlafaxine

Development stage
Approved
Lead developer
Pfizer
Modality
Small Molecules
Administration
Oral
01

Overview

Venlafaxine is a synthetic small molecule antidepressant classified as a selective serotonin and norepinephrine reuptake inhibitor (SNRI). It is primarily used to treat major depressive disorder, generalized anxiety disorder, social anxiety disorder, and panic disorder in adults. Venlafaxine works by inhibiting the reuptake of serotonin at lower doses and both serotonin and norepinephrine at higher doses, increasing their levels in the brain to help maintain mental balance. It also has weak inhibitory effects on dopamine reuptake at high doses. The drug was first approved for use in 1993 (immediate-release) with an extended-release formulation introduced later[1][2][5][6][8].

Brand names
EffexorEffexor XR
Other names
venlafaxine hydrochloride extended-release capsules
02

Targets

NET (Norepinephrine Transporter)DAT (Dopamine plasma membrane transport protein)SERT (Sodium-dependent serotonin transporter)

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