verapamil + citicoline

Verapamil + citicoline is a combination of two active pharmaceutical ingredients. Verapamil is a non-dihydropyridine calcium channel blocker primarily used to treat hypertension, angina, and certain arrhythmias by inhibiting L-type calcium channels in cardiac and vascular smooth muscle, leading to vasodilation and reduced cardiac workload[1][7]. Citicoline (cytidine-5'-diphosphocholine) is a neuroprotective agent that serves as an intermediate in the biosynthesis of phosphatidylcholine, supporting membrane repair and neurotransmitter synthesis. It has been investigated for its potential benefits in neurological disorders such as stroke and cognitive impairment. While there are no widely marketed fixed-dose combinations of verapamil with citicoline, preclinical studies suggest that combining an L-type calcium channel blocker (such as azelnidipine or potentially verapamil) with citicoline may provide synergistic neuroprotection against ischemic brain injury by reducing excitotoxicity, oxidative stress, apoptosis, infarction size, and improving motor function[5]. The rationale for this combination lies in dual mechanisms—verapamil’s vascular/neuroprotective effects via calcium channel blockade (and possibly microglial PHOX inhibition), together with citicoline’s membrane-stabilizing and anti-excitotoxic properties.

Other names

Superselective Citicoline and VerapamilSCAVINGER