Drug intelligence / Profile preview

verbascox

Development stage
Unknown
Lead developer
Labiotre
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Verbascox is a proprietary **botanical extract** standardized to contain at least 5% verbascoside (a phenylethanoid glycoside) and 2% aucubin (an iridoid glycoside), derived from the union of *Lippia citriodora* (lemon verbena) and *Plantago lanceolata* (plantain)[4][5][7]. It is formulated as a **granular extract** produced by LaBiotre using water/ethanolic extraction. The extract has been studied primarily for its **anti-inflammatory and analgesic properties**, acting as a *selective cyclooxygenase-2 (COX-2) inhibitor* without significant inhibition of COX-1[1][3][5]. Preclinical and early clinical studies indicate that Verbascox can reduce pain, improve functional capacity, and lower serum substance P in mild-to-moderate osteoarthritis of the knee, with efficacy comparable to celecoxib over a two-week course[1][3][5]. The extract is considered safe and non-cytotoxic in human neutrophils and is positioned as a plant-based alternative to synthetic COX-2 inhibitors for joint and musculoskeletal support[1][3][5].

Brand names
verbascox
Other names
verbascox
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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