Drug intelligence / Profile preview

Vestasync

Development stage
Discontinued
Lead developer
MIV Therapeutics
Modality
Small Molecules, Device-based Delivery → Drug Delivery Systems
Administration
Implant
01

Overview

VESTAsync is a polymer-free drug-eluting stent (DES) developed for the treatment of coronary artery disease. It features a nanometer-thin coating of hydroxyapatite (HA), a biocompatible mineral found in human bone, which serves as a reservoir for the anti-proliferative drug sirolimus (55 µg). The device is designed to address the inflammatory issues associated with permanent polymer coatings used in traditional DES. By releasing sirolimus, the stent inhibits neointimal hyperplasia, the primary cause of restenosis after angioplasty. Clinical trials, including VESTASYNC I and II, showed promising safety and efficacy, with low late lumen loss and no major adverse cardiac events (MACE) reported in early follow-ups. The hydroxyapatite coating is designed to be stable for approximately four months and completely dissolve after nine months, leaving behind a bare metal stent surface.

Brand names
VESTAsync
Other names
VESTAsync drug-eluting stent
02

Targets

FKBP1AmTOR (Mammalian target of rapamycin kinase)

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