VG9-GMCSF

VG9-GMCSF is a recombinant, **oncolytic vaccinia virus** based on the attenuated Chinese Tian Tan strain Guang9 (VG9), engineered to express **granulocyte-macrophage colony-stimulating factor (GM-CSF)** (specifically murine GM-CSF in published studies). This construct combines direct tumor cell lysis by the virus with immune stimulation via GM-CSF production, enhancing antitumor immunity. Preclinical studies in murine melanoma models show that VG9-GMCSF can significantly inhibit tumor growth and prolong survival, with efficacy attributed to both viral oncolysis and GM-CSF-driven activation of host immune responses[2][4]. The approach is akin to other oncolytic viruses armed with immunostimulatory cytokines but utilizes the VG9 strain, which is highly attenuated and distinct from more widely studied Western strains.

Other names

VG9-GMCSFVG-9-GMCSFVG 9-GMCSF