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Drug intelligence / Profile preview
Vi capsular polysaccharide vaccine
- Development stage
- Approved
- Lead developer
- Parent
- Modality
- Split/Subunit Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics, Recombinant Protein Vaccines → Recombinant Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
Vi capsular polysaccharide vaccine (Vi-PS) is a subunit vaccine used to prevent typhoid fever. It contains purified Vi polysaccharide extracted from Salmonella enterica serovar Typhi. Each 0.5 mL dose contains 25 mcg of purified Vi polysaccharide in a phosphate buffered saline solution. The vaccine induces a T cell-independent B cell response and provides protection for approximately 2 years, with an efficacy of about 55% in older children and adults. It is administered as an intramuscular injection and is indicated for use in individuals 2 years of age and older.
- Brand names
- Typhim ViTypherix
- Other names
- ViPSVi polysaccharide vaccine
02
Targets
Vi antigen (Vi capsular polysaccharide)
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