vialinin a

Vialinin A is a natural p-terphenyl compound isolated from edible mushrooms, notably *Thelephora vialis* and *Thelephora terrestris*. It acts as a potent inhibitor of several deubiquitinating enzymes, most notably ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T, and UCH-L1, with reported IC50 values of 1.5 μM (USP4), 5.9 μM (USP5/isopeptidase T), and 22.3 μM (UCH-L1)[1][2][3]. Vialinin A exhibits anti-inflammatory, antioxidant, anti-allergic, and antiangiogenic activities. It inhibits release of tumour necrosis factor alpha (TNF-α), interleukin 4, β-hexosaminidase, and monocyte chemotactic protein 1 in mast cells, and suppresses the production of angiogenic cytokines (e.g., angiopoietin-2, G-CSF, HB-EGF, HGF) in human vascular endothelial cells[1][3][4]. It blocks VEGF-induced neovascularization both in vitro and in vivo, primarily by inhibiting ROS generation and NF-κB nuclear translocation, and reduces inflammation and fibrosis by regulating the Rheb/mTOR signaling pathway[2][4].

Brand names

vialinin a

Other names

vialinin ap-terphenyl antioxidant