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VIB-1116
- Development stage
- Phase 1
- Lead developer
- Amgen
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Subcutaneous
01
Overview
VIB-1116 is a monoclonal antibody designed to decrease the number and function of antigen-presenting dendritic cells. It acts as an inhibitor of dendritic cells and modulates Fms-related tyrosine kinase 3 ligand (Flt3L), thereby reducing the activity of both conventional and plasmacytoid dendritic cells. The drug is being developed primarily for autoimmune conditions, with its main indication currently in Sjögren's syndrome. Initial development was by Viela Bio, with subsequent development by Amgen and Horizon Therapeutics. Clinical trials are ongoing to assess its safety, tolerability, pharmacokinetics, and efficacy in rheumatic diseases associated with dendritic cell dysfunction[1][2][4][7].
- Other names
- AMG-329AMG329AMG 329VIB-1116VIB1116VIB 1116
02
Targets
FLT3LG (FLT3 ligand)
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