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Vibrio cholerae Ogawa 50 classical biotype, formalin inactivated
- Development stage
- Unknown
- Lead developer
- Valneva
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Vaccines & Immunotherapeutics
- Administration
- Oral
01
Overview
Vibrio cholerae Ogawa 50 classical biotype, formalin inactivated is a component of several oral inactivated whole-cell vaccines used for the prevention of cholera. It consists of the O1 Ogawa serotype (classical biotype) of Vibrio cholerae that has been killed by treatment with formalin. This antigen is included alongside other V. cholerae strains and recombinant B subunit of cholera toxin to induce immunity against infection by stimulating an immune response to both bacterial surface antigens and the toxin[5][7][8]. The vaccine is administered orally and has demonstrated high efficacy against clinical disease caused by V. cholerae O1[5]. It is primarily indicated for prophylaxis against epidemic or travel-related risk of cholera.
- Brand names
- DukoralEuvichol
- Other names
- V. cholerae O1 Ogawa classical strain Cairo 50 formalin inactivated
02
Targets
CTBS (Cholera toxin B subunit)V. cholerae O1 LPS (Vibrio cholerae O1 lipopolysaccharide)
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