Drug intelligence / Profile preview

vilazodone

Development stage
Approved
Lead developer
Clinical Data
Modality
Small Molecules
Administration
Oral
01

Overview

Vilazodone is an oral antidepressant approved for the treatment of major depressive disorder (MDD) in adults. It is classified as a serotonin modulator and acts as both a selective serotonin reuptake inhibitor (SSRI) and a partial agonist at the serotonin 5-hydroxytryptamine 1A (5HT1A) receptor. By inhibiting the reuptake of serotonin and partially stimulating the 5HT1A receptor, vilazodone increases serotonergic activity in the central nervous system, which is associated with its antidepressant effects. Vilazodone was first approved by the FDA in January 2011[7][10]. It may be associated with less sexual dysfunction and weight gain compared to some other antidepressants[7].

Brand names
ViibrydViibryd Starter
Other names
vilazodonavilazodonum
02

Targets

SERT (Sodium-dependent serotonin transporter)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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