Vimang + methotrexate

A combination therapy that consists of Mangifera indica L. extract (Vimang) and methotrexate. This combination has been studied for potential therapeutic effects, particularly in the context of treatment regimens. ## Components **Vimang (Mangifera indica L. extract)** Vimang is a standardized extract from the stem bark of Mangifera indica L. (mango tree). It is available in tablet form, with studies using a dosage of 300 mg[1][2]. **Methotrexate** Methotrexate is a well-established antineoplastic and immunosuppressive agent that inhibits several enzymes responsible for nucleotide synthesis. It is used to treat various conditions including: - Rheumatoid arthritis - Psoriasis - Acute lymphoblastic leukemia - Non-Hodgkin's lymphomas - Trophoblastic diseases Methotrexate works by suppressing inflammation and preventing cell division, making it effective for both inflammatory conditions and neoplastic diseases[4]. ## Therapeutic Use The combination of Vimang and methotrexate has been studied for its therapeutic effects and safety profile. The research suggests this combination approach may offer benefits in certain treatment contexts, though specific indications are not fully detailed in the available search results[1][2]. ## Administration When used in combination therapy: - Vimang is administered as tablets (300 mg)[1][2] - Methotrexate dosing varies by condition, but for rheumatoid arthritis, it's typically taken once weekly rather than daily[3] ## Safety Considerations Methotrexate has several important safety considerations: - **Liver damage**: May cause severe or life-threatening liver damage, especially with long-term use[3] - **Lung damage**: Can cause severe or life-threatening lung damage[3] - **GI toxicity**: May damage the lining of the mouth, stomach, or intestines[3] - **Bone marrow suppression**: Can cause severe pancytopenia, anemia, and other blood disorders[7] - **Infections**: Life-threatening bacterial, fungal, or viral infections have occurred[7] When using methotrexate in combination therapy, careful monitoring is essential to prevent adverse effects. ## Combination Therapy Context Methotrexate is commonly used in combination with other drugs for various conditions. For rheumatoid arthritis, it serves as the foundation of many combination therapies, including double therapy (methotrexate plus another DMARD) and triple therapy approaches[5].

Other names

Mangifera indica L. extract + methotrexate