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vincristine
- Development stage
- Approved
- Lead developer
- Eli Lilly
- Modality
- Nucleic Acid-Directed Small Molecules → Small Molecules, Covalent Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Intravenous
01
Overview
Vincristine is a naturally occurring vinca alkaloid and antineoplastic agent used primarily in the treatment of various cancers. It acts as an antimicrotubule agent by binding to tubulin and inhibiting microtubule formation, thereby arresting cell division at metaphase and leading to cell death. Vincristine is considered cell cycle phase-specific for the M phase and S phase. It is most commonly used in combination chemotherapy regimens for acute lymphoblastic leukemia (ALL), Hodgkin lymphoma, non-Hodgkin lymphoma, Wilms tumor, neuroblastoma, rhabdomyosarcoma, choriocarcinoma, Ewing's sarcoma, gestational trophoblastic tumors, chronic lymphocytic leukemia (CLL), multiple myeloma (in some cases), Kaposi's sarcoma related to AIDS, certain brain tumors and lung cancers. Vincristine also has immunosuppressive effects[1][2][4][9].
- Brand names
- OncovinVincasar PFS
- Other names
- vincristine sulfateleurocristine
02
Targets
TUBB (Tubulin (alpha and beta subunits))DNA
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