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vincristine sulfate liposome
- Development stage
- Phase 3
- Lead developer
- Acrotech Biopharma
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Intravenous
01
Overview
Vincristine sulfate liposome is a sphingomyelin/cholesterol-based, nanoparticle (liposomal) formulation of the anticancer agent vincristine. It is designed to optimize delivery and prolong circulation time compared to standard vincristine, allowing for higher dosing with reduced toxicity. Vincristine acts as a **tubulin polymerization inhibitor**, disrupting microtubule formation and arresting cell division in the M phase of the cell cycle. The drug is primarily indicated for adults with Philadelphia chromosome-negative acute lymphoblastic leukemia (Ph– ALL) that has relapsed or progressed after at least two prior therapies. It has also been studied in non-Hodgkin's lymphoma and other cancers[1][3][4][5][6]. Developed by Inex Pharmaceuticals Corporation, Acrotech Biopharma, CASI Pharmaceuticals, Hana Biosciences, Talon Therapeutics, and University of Texas M. D. Anderson Cancer Center, and manufactured by Acrotech Biopharma.
- Brand names
- Marqibo
- Other names
- vincristine liposomevincristine sulfate injectionvincristine sulfate liposomes injectionvincacine
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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