vindesine

Vindesine is a semisynthetic vinca alkaloid derived from vinblastine and the plant Catharanthus roseus. It acts as an antimitotic chemotherapy agent by binding to β-tubulin subunits of microtubules at the so-called "vinca site," inhibiting microtubule dynamics. This leads to mitotic arrest in metaphase and subsequent cell death. Vindesine is cell cycle phase-specific (S phase) and is used primarily for treating various malignancies including acute lymphocytic leukemia (ALL), lymphoma (including Hodgkin's disease), melanoma, breast cancer, and non-small cell lung cancer. Major side effects include myelosuppression and neurotoxicity.

Brand names

Eldisine

Other names

desacetylvinblastine amidevindesinavindesinumvindesine sulfate