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vinorelbine + cyclophosphamide + interferon alpha 2b
- Development stage
- Unknown
- Lead developer
- Pierre Fabre
- Modality
- Small Molecules, Recombinant Proteins and Enzymes
- Administration
- Oral, Intravenous, Subcutaneous, Intramuscular
01
Overview
This is a combination regimen consisting of three agents—vinorelbine, cyclophosphamide, and interferon alpha 2b—used primarily in investigational settings for the treatment of advanced neoplasms. Vinorelbine is a semi-synthetic vinca alkaloid that inhibits mitosis by binding to tubulin and disrupting microtubule formation in dividing cells. Cyclophosphamide is an alkylating agent that crosslinks DNA strands, leading to cell death. Interferon alpha 2b is a recombinant cytokine with immunomodulatory, antiproliferative, and antiangiogenic properties. The combination has been studied as "metronomic chemotherapy," where low continuous doses are administered to exert antiangiogenic effects while minimizing toxicity[1][2][8]. This regimen aims to target both tumor cells directly (cytotoxicity) and the tumor microenvironment (antiangiogenesis/immunomodulation).
- Brand names
- EndoxanIntrona
- Other names
- vinorelbine and cyclophosphamide and interferon alfa-2bmetronomic chemotherapy with vinorelbine, cyclophosphamide, and interferon alpha 2b
02
Targets
DNATUBB (Tubulin (alpha and beta subunits))IFNAR (Immune system modulation via type I interferon receptor)
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