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vinzolidine
- Development stage
- Unknown
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules, Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Oral, Intravenous
01
Overview
Vinzolidine is a semisynthetic derivative of vinblastine, belonging to the vinca alkaloid class of antineoplastic agents. It exhibits antitumor activity by interfering with microtubule dynamics, specifically by inhibiting tubulin polymerization into microtubules. This disruption leads to cell cycle arrest and apoptosis in malignant cells. Vinzolidine has shown in vitro activity against various solid tumors, including melanoma, lung cancer, breast cancer, renal cancer, ovarian cancer, colon cancer, pancreatic cancer, and gastric cancer. It has been investigated in clinical trials for advanced cancer.
02
Targets
TUBB (Tubulin (alpha and beta subunits))
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