Drug intelligence / Profile preview

viola mandshurica

Development stage
Preclinical
Administration
Oral, Topical
01

Overview

**Viola mandshurica** is a perennial herb in the Violaceae family, native to East Asia (Korea, Japan, China, Russia, and Siberia), used historically in traditional medicine. It has been studied for various biological activities, particularly as an **anti-inflammatory**, expectorant, and diuretic. Extracts (notably fermented and chloroform extracts) demonstrate suppression of pro-inflammatory mediators by inhibiting inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), as well as the NF-κB, ERK, and JNK pathways. Identified constituents include tectoridin, luteolin, resveratrol, and hesperetin. It has been investigated for uses in bronchitis, rheumatism, skin eruptions, eczema, asthma, obesity, hyperlipidemia, and possibly viral infections. Usage is primarily as a **dietary supplement/herbal extract** in traditional practices, not a regulated pharmaceutical drug[1][2][3][4][5][6].

Other names
Manchurian violetdōng běi jǐn cài
02

Targets

JNK (Mitogen-activated protein kinase kinase kinase family)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)NOS2 (Nitric Oxide Synthase 2)NF-κBMAPK3 (Mitogen-activated protein kinase 1)

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