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Violet Balm
- Development stage
- Unknown
- Lead developer
- Vireo Health International
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Topical
01
Overview
Violet Balm (also known as Dr. Westwater Violet Balm) is a CBD-dominant topical cream developed by Vireo Health (a subsidiary of Goodness Growth Holdings) containing 2210 mg of cannabidiol (CBD) per jar and less than 0.3% tetrahydrocannabinol (THC). It is formulated with a lipid mixture and enhanced with terpenes to improve skin penetration and fragrance. Violet Balm is being evaluated in clinical trials, such as the CanAroma study led by the University of Minnesota, for the treatment of aromatase inhibitor-associated musculoskeletal syndrome (AIMSS) in breast cancer patients. Cannabidiol acts as a multi-target modulator, including negative allosteric modulation of cannabinoid receptors (CB1 and CB2), agonism of transient receptor potential vanilloid 1 (TRPV1) and 5-HT1A receptors, and antagonism of GPR55.
- Brand names
- Dr. Westwater Violet BalmViolet Balm
- Other names
- CBD-dominantCBD-dominant creamVioletViolet cream
02
Targets
HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))CNR1 (Cannabinoid receptor 1)GPR55 (G protein-coupled receptor 55)TRPV1 (Transient receptor potential cation channel subfamily V member 1)
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