viomycin

Viomycin is a cyclic polypeptide antibiotic of the tuberactinomycin family, originally isolated from the actinomycete Streptomyces puniceus. It was historically used to treat tuberculosis, particularly infections caused by Mycobacterium tuberculosis, but has largely been replaced by the less toxic capreomycin. Viomycin acts by binding to bacterial ribosomal RNA at multiple sites, especially at the interface between helix 44 of the small ribosomal subunit and helix 69 of the large subunit. This binding inhibits protein synthesis by blocking elongation factor G (EF-G) catalyzed translocation during translation and stabilizing tRNA in the A site in a pretranslocation state. The result is inhibition of bacterial protein synthesis and disruption of certain forms of RNA splicing[1][2][3][4][5][6].

Brand names

Viocin

Other names

viomycineviomicinaviomycinumceliomycinflorimycinvioactane