vipera ammodytes venom

Vipera ammodytes venom, derived from the nose-horned viper, is a complex biological mixture being investigated for its potential in oncology, particularly for the treatment of malignant melanoma. Proteomic analysis of the venom reveals a high abundance of Phospholipases A2, C-type lectins, and snake venom metalloproteinases (SVMPs), which contribute to its cytotoxic, anti-proliferative, and tumor-inhibiting properties. In preclinical in vitro studies, the venom has demonstrated significant cytotoxicity against various melanoma cell lines (M001, Me501, and A375) and has shown a potent chemosensitising effect when combined with cisplatin. This synergy is especially notable in cisplatin-resistant cell lines, where the venom enhances cell mortality by up to 40%. The venom's mechanism involves inducing morphological changes and selective targeting of cancer cells, positioning it as a potential therapeutic adjuvant for advanced or metastatic melanoma.

Other names

nose-horned viper venomsand viper venom