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VIR-5525 + pembrolizumab
- Development stage
- Phase 1
- Lead developer
- Vir Biotechnology
- Modality
- T-cell Engagers → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
VIR-5525 + pembrolizumab is a combination investigational therapy for solid tumors expressing EGFR, currently in Phase 1 clinical trials. VIR-5525 is a dual-masked T-cell engager (TCE) that utilizes PRO-XTEN masking technology to selectively activate within the tumor microenvironment, aiming to mitigate damage to healthy cells and reduce toxicity. It targets the epidermal growth factor receptor (EGFR) to direct T-cell-mediated killing of cancer cells. Pembrolizumab is a monoclonal antibody and immune checkpoint inhibitor that blocks PD-1, preventing tumor cells from evading immune attack and enhancing T-cell response. This combination is intended to leverage both direct T-cell targeting of EGFR-positive tumors (via VIR-5525) and immune checkpoint blockade (via pembrolizumab), potentially improving anti-tumor efficacy in advanced, locally advanced, or metastatic solid malignancies with EGFR expression. The lead developer is Vir Biotechnology[1][2][3][4][5][6][7].
- Other names
- VIR-5525 + pembrolizumab
02
Targets
CD3 (T-cell surface glycoprotein CD3)EGFR (Epidermal growth factor receptor)PDCD1 (Programmed cell death protein 1 receptor)
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