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Vir Biotechnology HIV monoclonal antibodies

Development stage
Preclinical
Lead developer
Vir Biotechnology
Modality
Monoclonal Antibodies → Antibody-Based Therapeutics
Administration
Intravenous, Subcutaneous, Intramuscular
01

Overview

Vir Biotechnology, through its subsidiary Humabs BioMed, is developing a portfolio of preclinical monoclonal antibody candidates aimed at achieving a functional cure for HIV. Developed in collaboration with the Bill & Melinda Gates Foundation, these antibodies target undisclosed HIV-1 viral antigens. The candidates are discovered using Humabs' proprietary CellClone technology, which enables the isolation of rare, fully human antibodies from the memory B cells of convalescent patients. This program focuses on identifying potent neutralizing antibodies that can potentially eliminate viral reservoirs or provide long-term viral suppression as part of HIV cure-focused research.

Other names
Preclinical antibody candidates (HIV)Humabs HIV antibodiesPreclinical antibody candidates (Gates Foundation collaboration)
02

Targets

gp41 (Human immunodeficiency virus type 1 glycoprotein 41)Env (HIV-1 envelope glycoprotein)gp120 (HIV-1 envelope glycoprotein (gp120/gp41) epitopes)

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