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ViroTCell
- Development stage
- Phase 1
- Lead developer
- Banc de Sang i Teixits
- Modality
- Cell Therapies
- Administration
- Intravenous
01
Overview
ViroTCell is an investigational donor-derived virus-specific T lymphocyte (VST) therapy developed by Banc de Sang i Teixits (BST) in collaboration with the Vall d'Hebron Institut d'Oncologia (VHIO). It consists of cytomegalovirus (CMV)-specific T cells obtained from donors, designed to provide adoptive T-cell immunotherapy for recipients of allogeneic hematopoietic stem cell transplantation (HSCT) who develop CMV infections. The therapy aims to restore CMV-specific immunity in immunocompromised patients. It is currently being evaluated in a Phase Ib-II clinical trial in Spain, representing the first antiviral cell therapy trial produced entirely within the country.
- Other names
- donor-derived CMV-specific T lymphocytesvirus-specific T lymphocytes
02
Targets
IE1 (HCMV immediate-early protein 1)Cytomegalovirus peptide–Human Leukocyte Antigen class II complex (CMV–HLA-II complex)pp65/HLA-A*02:01 (CMV pp65 peptide-HLA-A*02:01 complex)
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