Drug intelligence / Profile preview

vitamin a

Development stage
Approved
Lead developer
Robinson Pharma
Modality
Small Molecules
Administration
Oral, Intramuscular, Intravenous, Topical, Ophthalmic
01

Overview

Vitamin A is an essential fat-soluble vitamin that encompasses a group of related compounds including retinol (the alcohol form), retinal (the aldehyde form), and several provitamin carotenoids such as beta-carotene. It is crucial for vision (as it forms rhodopsin in the retina), immune function, reproduction, cellular growth and differentiation (especially epithelial tissue), bone development and hematopoiesis. Vitamin A acts primarily through its active metabolite all-trans-retinoic acid which binds to nuclear receptors—retinoic acid receptors (RARs) and retinoid-X receptors (RXRs)—to regulate gene transcription. It is used clinically to prevent or treat vitamin A deficiency disorders such as xerophthalmia and night blindness[1][3][5]. Vitamin A also has antioxidant properties[1][2].

Brand names
Aquasol AInfuviteInfuvite PediatricMvc-fluorideMvi PediatricVitafol-oneA-25A25A 25A/Fish OilXcellent A 3000Xcellent A
Other names
retinolretinoic acidretinyl esters
02

Targets

RXRG (RXRγ)RARB (Retinoic acid receptor beta)RXRA (Retinoid X receptor alpha)RXRB (Retinoid X receptor beta)RARG (Retinoic acid receptor gamma)RARA (Retinoic acid receptor alpha)

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