Drug intelligence / Profile preview

vitamin b12

Development stage
Phase 4
Lead developer
Copka Sonpashan
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Intramuscular, Oral, Intravenous, Perineural
01

Overview

Vitamin B12, also known as cobalamin, is an essential water-soluble vitamin that plays a critical role in DNA synthesis, methylation, and mitochondrial metabolism. It serves as a vital cofactor for enzymes such as methionine synthase and methylmalonyl-CoA mutase, which are necessary for the maintenance of the central nervous system and the formation of the myelin sheath. In the provided clinical context, Vitamin B12 is being investigated as a component of Stellate Ganglion Block (SGB) therapy, typically administered in combination with local anesthetics like lidocaine. This therapeutic approach is being evaluated for its efficacy in treating functional and neurological impairments, including dysphagia, cognitive impairment, and drooling in patients with Cerebral Small Vessel Disease (CSVD), traumatic brain injury, and Parkinson's syndrome. The rationale for its use in these procedures involves its potential neuroprotective and nerve-regenerative properties.

Brand names
Animi-3 With Vitamin DAnimi3 With Vitamin DAnimi 3 With Vitamin DB-12B12B 12CobexConcept ObDodexFerralet 90Ferralet90Ferralet-90FolbicFoltabsFortaplexHematogenInfuviteInfuvite PediatricIrospan 24/6 KitMvc-fluorideMvi PediatricNascobalNatafortPregvitTandem PlusVitafol-oneMethyl B-12Vitamin B12 Methylcobalamin
Other names
cyanocobalaminmethylcobalaminhydroxocobalaminadenosylcobalamincobalamin
02

Targets

MTR (Methionine synthase)

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