Drug intelligence / Profile preview

vitamin e

Development stage
Phase 4
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
Administration
Oral, Topical, Intramuscular
01

Overview

Vitamin E is a collective term for a group of eight fat-soluble compounds known as tocopherols and tocotrienols. The most biologically active form in humans is alpha-tocopherol. Vitamin E functions primarily as an antioxidant, protecting cell membranes from oxidative damage by neutralizing free radicals. It also plays roles in immune function, gene expression regulation, inhibition of protein kinase C activity (affecting cell proliferation and differentiation), and modulation of vascular function by increasing prostacyclin release and inhibiting platelet aggregation. Vitamin E is essential for neurological function and blood clotting support[1][4][8]. It is used to treat or prevent vitamin E deficiency—most commonly seen in individuals with malabsorption syndromes such as cystic fibrosis or certain liver diseases—and has been studied for potential benefits in conditions like Alzheimer's disease, nonalcoholic fatty liver disease (NAFLD), beta-thalassemia, dysmenorrhea (menstrual pain), tardive dyskinesia, ataxia with vitamin E deficiency (AVED), among others[3][5][10]. While widely available over the counter as capsules or liquid drops alone or combined with other vitamins[1], high-dose supplementation may carry risks such as increased bleeding tendency.

Brand names
Aquasol E
Other names
alpha-tocopheroltocopherold-alpha-tocopheryl acetated-alpha-tocopheryl succinateall-rac-alpha-tocopherolRRR-alpha-tocopheroltocotrienol
02

Targets

PRKCA (Protein kinase C alpha)

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