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vitis vinifera fraction 1
- Development stage
- Preclinical
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral, Sublingual
01
Overview
**Vitis vinifera fraction 1** is an experimentally studied **polyphenol-enriched botanical extract** isolated from the pulp and skin of seedless black *Vitis vinifera* fruit. It has been evaluated in academic preclinical models as a hepatoprotective and anticancer research agent, particularly in hepatotoxicity and hepatocellular carcinoma settings. Reported activity appears to be multi-mechanistic rather than directed at a single defined molecular target, with effects that include antioxidant and anti-inflammatory activity, reduction of necroptosis-associated signaling, suppression of pro-fibrotic mediators such as mixed lineage kinase domain-like protein, collagen type I alpha 1 chain, and transforming growth factor beta 1, and induction of apoptosis in liver cancer models. Available evidence is limited to preclinical research, with no identified commercial sponsor, marketed product, or established pharmaceutical development program.
- Other names
- vitis vinifera fraction 1seedless black Vitis vinifera fraction 1Vitis vinifera polyphenolic fraction 1
02
Targets
HDAC1 (Histone Deacetylase 1)MLKL (Mixed lineage kinase domain-like protein)NOX2 (NADPH oxidase 2)SPR (Sepiapterin reductase)TGFB1 (Transforming growth factor Beta-1 proprotein)
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