Vivostat

Vivostat is an autologous fibrin sealant and platelet-rich fibrin (PRF) system used in various surgical procedures. The system processes a patient's own blood to create specialized solutions for hemostasis, tissue sealing, and tissue regeneration. **System Overview** Vivostat is a patented biotechnological process that enables the preparation of autologous fibrin sealant and platelet-rich fibrin matrices without using cryoprecipitation or requiring a separate thrombin component[3]. The system processes 120 ml of a patient's blood to produce 5-6 ml of concentrated solution that can be used for various surgical applications[4][5]. The preparation process involves three simple steps: 1. Adding citrate to the Preparation Unit and drawing 120 ml of the patient's blood 2. Processing the blood in the Processor Unit (takes approximately 25 minutes) 3. Loading the resulting solution into the Applicator Unit for application at the surgical site[3] **Product Variants** Vivostat offers several product variants: 1. **Vivostat Fibrin** - An autologous concentrated fibrin sealant for hemostasis and tissue sealing[3] 2. **Vivostat PRF (Platelet Rich Fibrin)** - Combines platelets with fibrin to create a matrix for tissue regeneration[4][5] 3. **ArthroZheal** - Specifically designed for arthroscopic surgery and orthopedic applications[6] **Clinical Applications** Vivostat is used across numerous surgical specialties: - **Vascular Surgery** - For handling bleeding and infection challenges[1] - **General Surgery** - With co-delivery options for medications like antibiotics[2] - **Neurosurgery** - For hemostasis and dural sealing[9] - **Orthopedic Surgery** - For tissue regeneration and hemostasis in procedures like: - Arthroscopic knee, hip, shoulder, and ankle surgeries - Joint replacements - Infiltrations in joints, tendons, and ligaments[6] - **Wound Treatment** - For chronic or complicated wounds[8][10] - **Other specialties** - Including abdominal, burn, cardiac, ENT, fistula, maxillofacial, and spine surgeries[4] **Key Features and Benefits** 1. **Autologous Nature** - Uses the patient's own blood, ensuring excellent biocompatibility[3][7] 2. **Co-Delivery System** - Allows simultaneous application of medications (antibiotics, chemotherapeutics, pain medications) or cells (stem cells, skin cells)[7] 3. **Controlled Release** - The fibrin matrix ensures slow release of growth factors and protection against degradation[5] 4. **No Thrombin Component** - Unlike conventional products, no thrombin is added, which is beneficial for cell survival in co-delivery applications[7] 5. **Versatility** - Can be prepared and used intermittently throughout lengthy operations without loss of properties (stable for up to 8 hours at room temperature)[4] **Clinical Efficacy** A retrospective study of 35 patients with chronic or complicated wounds treated with Vivostat PRF showed that 77.1% of patients benefited from the therapy, with 40% achieving complete epithelialization[8][10]. The positive effects were typically observed within the first three to six applications[10]. The system has also proven effective in neurosurgical applications, with only 2 cases of postoperative CSF fistulas reported in one study, and no local medullar toxicity, allergic reactions, infections, or systemic complications[9].

Brand names

VivostatVivostat PRFArthroZheal

Other names

Vivostat FibrinVivostat Platelet-Rich FibrinVivostat System