Drug intelligence / Profile preview

VL#FIA3-30

Development stage
Unknown
Lead developer
VasoLead
Modality
Small Molecules
Administration
Topical
01

Overview

**VL#FIA3-30** is an investigational topical fixed-dose vasodilator combination developed by VasoLead for erectile dysfunction. Published reports describing this exact product identify its active ingredients as moxisylyte and isosorbide dinitrate, delivered with a tunica-penetrable topical delivery system for penile application. Moxisylyte blocks alpha-1 adrenergic receptor-mediated vasoconstriction, while isosorbide dinitrate serves as a nitric-oxide donor that promotes cyclic GMP-mediated smooth-muscle relaxation and penile engorgement. The product was evaluated in a Phase 1/2 study in men with erectile dysfunction. ([academic.oup.com](https://academic.oup.com/jsm/article-abstract/14/Supplement_4a/e179/6994869))

Other names
moxisylyte + isosorbide dinitratemoxisylyte/isosorbide dinitrate
02

Targets

sGC (Soluble Guanylyl Cyclase)ADRA1A (α1A)

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