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VL#FIA3-30 (VasoLead)
- Development stage
- Unknown
- Lead developer
- VasoLead
- Modality
- Small Molecules
- Administration
- Topical
01
Overview
**VL#FIA3-30** is VasoLead's investigational topical fixed-dose vasodilator combination for erectile dysfunction. Published clinical material identifies the active ingredients as **moxisylyte** and **isosorbide dinitrate**, formulated with a tunica-penetrable delivery system for penile application. Moxisylyte is an alpha-1 adrenergic receptor antagonist that promotes local vascular smooth-muscle relaxation, while isosorbide dinitrate is a nitric-oxide donor that activates soluble guanylate cyclase and increases cyclic GMP signaling, supporting corpus cavernosum smooth-muscle relaxation and penile blood flow. The product was evaluated in a Phase 1/2 randomized study in men with erectile dysfunction. ([academic.oup.com](https://academic.oup.com/jsm/article-abstract/14/Supplement_4a/e179/6994869))
- Other names
- MH30-01 + IS045-01moxisylyte + ISDNmoxisylyte + isosorbide dinitratemoxisylyte/isosorbide dinitrate
02
Targets
KATP channel (ATP-sensitive potassium channel)sGC (Soluble Guanylyl Cyclase)
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