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VLM oncology
- Development stage
- Preclinical
- Lead developer
- Virothera Pharmaceuticals
- Modality
- Prophylactic Vaccines → Vaccines & Immunotherapeutics, Gene Therapies, DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, RNA Therapeutics → Nucleic Acid Therapeutics, Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous
01
Overview
Virothera Pharmaceuticals is developing a nucleic acid-based immunotherapy using its proprietary Virus Like Membranes (VLM) platform. This specific program targets the C-C chemokine receptor type 5 (CCR5) for the treatment of breast cancer. The VLM technology utilizes non-replicating, non-integrating viral-like particles to deliver DNA or RNA intended to modulate the immune system or directly target oncogenic pathways. In breast cancer, CCR5 signaling is associated with tumor progression, metastasis, and the recruitment of immunosuppressive cells to the tumor microenvironment; therefore, targeting this receptor aims to inhibit these processes. The program is currently in the preclinical stage of development.
- Other names
- Virus Like MembranesVLM-CCR5VLM-CCR-5VLM-CCR 5
02
Targets
CCR5 (C-C chemokine receptor type 5)
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