VO-OHpic

**VO-OHpic** is a potent, selective, and reversible small-molecule inhibitor of PTEN (phosphatase and tensin homolog), acting as a noncompetitive inhibitor with nanomolar affinity (IC50 35–46 nM) both in vitro and in vivo[1][2][3][4][5][6][7]. VO-OHpic increases cellular levels of PIP3, enhances Akt phosphorylation and glucose uptake, and is highly selective for PTEN over other phosphatases. In preclinical models, it promotes antitumor inflammatory responses and enhances effects of chemotherapy, making it a valuable research tool for studying PI3K/Akt signaling, cancer, and metabolism[1][2][7].

Other names

(OC-6-45)-Aqua(3-hydroxy-2-pyridinecarboxylato-κ-N1,κO2)[3-(hydroxy-κO)-2-pyridinecarboxylato(2-)-κO2]oxovanadate(1-),hydrogenhydron;hydroxy(oxo)vanadium;3-hydroxypyridine-2-carboxylic acid;trihydrateCAS 675848-25-6CAS675848-25-6CAS-675848-25-6CAS 476310-60-8CAS476310-60-8CAS-476310-60-8C12H18N2O11V+