voclosporin + mycophenolate mofetil + corticosteroids

**voclosporin + mycophenolate mofetil + corticosteroids** is a multi-drug combination regimen used primarily for the induction treatment of **lupus nephritis** (LN), an autoimmune kidney inflammation caused by systemic lupus erythematosus. - **Voclosporin** is a next-generation calcineurin inhibitor that suppresses T-cell activation and cytokine production, and promotes podocyte stability in the kidney. - **Mycophenolate mofetil** is a potent inhibitor of inosine monophosphate dehydrogenase, resulting in decreased proliferation of lymphocytes and thus acts as a broad immunosuppressant. - **Corticosteroids** (glucocorticoids) are synthetic steroid hormones that modulate inflammation and immune response by binding to the glucocorticoid receptor, regulating gene expression and decreasing pro-inflammatory cytokine levels. This combination has demonstrated **superior efficacy in inducing complete renal response** compared with mycophenolate mofetil and corticosteroids alone, significantly reducing proteinuria and improving renal outcomes in clinical trials[1][2][3]. Adverse events are similar to known immunosuppressive risks, most commonly infections[1][2][3][6].

Other names

voclosporin + MMF + steroidsvoclosporin + mycophenolate mofetil + glucocorticoids