Drug intelligence / Profile preview

voglibose + metformin (Zinnia Life Sciences)

Development stage
Phase 4
Lead developer
Zinnia Life Sciences
Modality
Small Molecules
Administration
Oral
01

Overview

Zinivog M is a fixed-dose combination of voglibose, an alpha-glucosidase inhibitor, and metformin hydrochloride, a biguanide antihyperglycemic agent. Developed by Zinnia Life Sciences, it is indicated for the management of type 2 diabetes mellitus, particularly to control postprandial and fasting blood glucose levels. Voglibose acts locally in the small intestine to delay carbohydrate digestion and absorption, thereby reducing post-meal blood sugar spikes. Metformin works primarily by decreasing hepatic glucose production, decreasing intestinal absorption of glucose, and improving insulin sensitivity by increasing peripheral glucose uptake and utilization.

Brand names
Zinivog MZinivog M 0.2Zinivog m 0.3Zinivog-M 0.3Zinivog-M0.3Zinivog-M-0.3
Other names
voglibose + metforminvoglibose + metformin hydrochloridevoglibose and metforminvoglibose and metformin hydrochloridevoglibose/metforminvoglibose/metformin hydrochloride
02

Targets

AMPK (Adenosine monophosphate–activated protein kinase)V-ATPase (Vacuolar-type H+-ATPase)GSEC (Gamma-Secretase Complex)ND1 (Mitochondrial electron transport chain complex I)Sucrase-Isomaltase

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