Drug intelligence / Profile preview

Volulyte

Development stage
Phase 4
Lead developer
Fresenius Kabi
Modality
Injectable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Implantable Hydrogels → Hydrogel Systems → Drug Delivery Systems, Non-biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Intravenous
01

Overview

**Volulyte** is a Fresenius Kabi intravenous balanced-colloid plasma volume expander containing 6% hydroxyethyl starch 130/0.4, a synthetic starch polymer derived from waxy maize, in an isotonic balanced electrolyte solution. The product increases intravascular oncotic volume by retaining fluid within the circulation and is used for volume replacement in hypovolemia due to acute blood loss when crystalloids alone are insufficient. Its electrolyte vehicle contains sodium, potassium, magnesium, chloride, and acetate; acetate acts as a bicarbonate precursor and the formulation has a lower chloride load than saline-based HES products. Volulyte has been evaluated in trauma, elective abdominal surgery, major burns, and cardiac surgery. Hydroxyethyl starch products have important safety restrictions, including avoidance in critically ill patients and patients with sepsis because of increased risks of mortality and renal replacement therapy. ([fresenius-kabi.com](https://www.fresenius-kabi.com/in/products/fluidtherapy/freeflexbag/volulyte))

Brand names
VolulyteVolulyte 6%
Other names
6% hydroxyethyl starch 130/0.4 in balanced electrolyte solution6% hydroxyethyl starch 130/0.4 in isotonic electrolyte injection
02

Targets

AMY (Pancreatic alpha-amylase)

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