Drug intelligence / Profile preview

Vonacor

Development stage
Unknown
Lead developer
Optimal Laboratories
Modality
Small Molecules
Administration
Oral
01

Overview

Vonacor is a dietary supplement and medical food designed for the dietary management of osteoarthritis and joint pain. Developed by Optimal Laboratories, a company founded by sports medicine physician Dr. Vad and pharmacist Steven Gelwan, the product features a specialized formulation of curcumin known as MicroActive Curcumin. This turmeric root extract is standardized to 25% curcuminoids and combined with turmeric oil in a 500mg capsule. Vonacor utilizes patented MicroActive microtechnology to enhance the bioavailability of curcumin, achieving a 9.7-fold increase in absorption compared to standard curcumin formulations. Mechanistically, Vonacor works by regulating the body's inflammatory response, specifically by blocking Interleukin-1 (IL-1) and modulating various inflammatory enzymes and cytokines to support joint health and mobility. The product is marketed as a vegan, non-GMO, and gluten-free option available through physicians' offices, pharmacies, and direct-to-consumer channels.

Brand names
Vonacor
02

Targets

MRP5 (ATP-binding cassette sub-family C member 5)IL-1R (Interleukin-1 receptor type 1 (IL-1R1))GSTM1 (Glutathione S-transferase Mu 1)ABCB1 (P-glycoprotein)GSTA1 (Glutathione S-transferase A1)CYP3A4 (Cytochrome P450 3A4)NF-κBGSTP1 (Glutathione S-transferase P)

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