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vonoprazan + amoxicillin (National Taiwan University Hospital)
- Development stage
- Phase 4
- Lead developer
- Phathom Pharmaceuticals
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
D-V14 is a 14-day dual therapy regimen investigated by the National Taiwan University Hospital for the first-line treatment of *Helicobacter pylori* infection. The regimen consists of vonoprazan, a potassium-competitive acid blocker (P-CAB), administered at 20 mg twice daily, and amoxicillin, a beta-lactam antibiotic, administered at 750 mg every 8 hours. Vonoprazan provides rapid, potent, and sustained suppression of gastric acid by competitively inhibiting the potassium-binding site of the gastric H+,K+-ATPase. This high level of acid suppression is critical for increasing the stability and efficacy of amoxicillin, which is highly pH-dependent, thereby improving eradication rates of *H. pylori* compared to traditional proton pump inhibitor (PPI)-based therapies.
- Brand names
- Vocinti
- Other names
- vonoprazan-based dual therapy for 14 days
02
Targets
ATP4A (Potassium–transporting ATPase alpha chain 1)PBP1A (Penicillin-binding protein 1A)
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