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VRC-HIVMAB0121-00-AB

Development stage: Phase 1
Lead developer: Vaccine Research Center
Modality: Bispecific Antibodies → Multispecific Antibodies → Engineered Antibody Formats → Antibody-Based Therapeutics
Administration: Intravenous, Subcutaneous

Overview

VRC-HIVMAB0121-00-AB (also known as CAP256J3LS) is a human bispecific broadly neutralizing monoclonal antibody developed for the prevention and treatment of HIV infection. It targets the HIV envelope protein gp120, a key component required for viral entry into host cells. By binding to gp120, this antibody can neutralize diverse strains of HIV and potentially prevent or treat infection. The drug is being evaluated in Phase 1 clinical trials to assess its safety and pharmacokinetics when administered intravenously or subcutaneously in healthy adults. The developer is the National Institute of Allergy & Infectious Diseases[2][9][1].

Other names: CAP256J3LSCAP-256J3LSCAP 256J3LSVrc-Hivmab0121-00-AbVrc-Hivmab-0121-00-AbVrc-Hivmab 0121-00-Ab

Targets

Env (HIV-1 envelope glycoprotein)

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