Drug intelligence / Profile preview

VRC-SRSDNA015-00-VP

Development stage: Phase 1
Lead developer: National Institute of Allergy and Infectious Diseases
Modality: DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics
Administration: Intramuscular

Overview

VRC-SRSDNA015-00-VP is a candidate DNA-based vaccine developed to prevent severe acute respiratory syndrome (SARS) caused by the original SARS coronavirus (SARS-CoV). The product consists of a single closed circular plasmid (VRC 8318) encoding a codon-modified, truncated version of the spike glycoprotein (SΔCD, Urbani strain), optimized for expression in human cells. The cytoplasmic domain is deleted to enhance immunogenicity.

Other names: VRC-SRSDNA015-00-VPVRC-SRSDNA-015-00-VPVRC-SRSDNA 015-00-VPSARS DNA vaccine - VRC/NIAIDCoronavirus DNA vaccine - VRC/NIAIDSARS recombinant DNA plasmid vaccine - VRC/NIAIDSevere acute respiratory syndrome DNA vaccine - VRC/NIAID

Targets

SARS-CoV-2 spike

Beyond the preview

Go deeper on VRC-SRSDNA015-00-VP.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on VRC-SRSDNA015-00-VP.

Explore the full profile