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VRP-001
- Development stage
- Preclinical
- Lead developer
- Venus Remedies
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Oral
01
Overview
VRP-001 is an orally available antibiotic adjuvant entity (AAE) and antibiotic resistance breaker (ARB) being developed by Venus Remedies for the treatment of bacterial infections, specifically multi-drug resistant Gram-negative infections. It is formulated using Venus Remedies' proprietary Stealth Targeted Nanoparticles (STN) platform technology, which utilizes a pH-sensitive, biodegradable, and biocompatible polymeric backbone. This stealth coating allows the nanoparticles to bypass macrophagic detection by the immune system, while a targeting moiety facilitates the oral delivery of drugs with low bioavailability (such as BCS Class III and IV compounds). VRP-001 acts as a beta-lactamase inhibitor to restore the efficacy of co-administered beta-lactam antibiotics against resistant pathogens. It is currently in preclinical development.
- Other names
- VRP 001VRP001VRP-001
02
Targets
β-lactamase
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