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VRP-048

Development stage: Preclinical
Lead developer: Venus Medicine Research Centre
Modality: Nanoparticles → Drug Delivery Systems, Small Molecules
Administration: Oral

Overview

VRP-048 is a preclinical-stage oral combination therapy developed by Venus Medicine Research Centre (VMRC) for the treatment of bacterial infections, particularly those involving antimicrobial resistance (AMR). The drug candidate combines meropenem, a broad-spectrum carbapenem antibiotic, with MET-X, a proprietary antibiotic resistance breaker (ARB). VRP-048 utilizes VMRC's Stealth Targeted Nanoparticles (STN) platform, which is engineered to facilitate the oral delivery of BCS Class III and IV antibiotics that are typically restricted to intravenous administration. By pairing a potent antibiotic with a resistance-breaking component in a specialized nanoparticle delivery system, VRP-048 aims to provide an effective oral alternative for managing multi-drug resistant bacterial infections.

Other names: meropenem + MET-X

Targets

PBP (Penicillin-binding protein family)

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