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VRP-BORIS
- Development stage
- Preclinical
- Lead developer
- University of California, Irvine
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Subcutaneous
01
Overview
VRP-BORIS (also known as VRP-mBORIS) is a therapeutic cancer vaccine consisting of a recombinant Venezuelan Equine Encephalitis (VEE) virus-like replicon particle (VRP) vector that expresses a modified version of the cancer-testis antigen Brother of Regulator of Imprinted Sites (BORIS, also known as CTCFL). The modified BORIS antigen lacks the DNA-binding zinc finger domain to prevent potential oncogenic activity and off-target autoimmune responses. VRP-BORIS is designed to target dendritic cells in vivo, promoting antigen presentation and eliciting a robust cellular immune response (including T-helper cell proliferation and interferon-gamma secretion) against BORIS-expressing cancer cells, particularly cancer stem cells. It has been investigated in preclinical models of breast cancer.
- Other names
- VEE-VRP-mBORISVRP-mBORIS
02
Targets
CTCFL (CCCTC-binding factor-like protein)
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